| 摘要 |
A method for the prevention, treatment, or amelioration of pain, inflammation, or inflammation-related disorder in a subject that is in need of such prevention, treatment or amelioration, involves the administration to the subject of a cyclooxygenase-2 selective inhibitor or prodrug thereof and enteric coated aspirin. A method can also involve the administration of a cyclooxygenase-2 selective inhibitor and aspirin in an amount lower than 75 mg/day. A method can also involve the administration of a cyclooxygenase-2 selective inhibitor and aspirin where the cycloxygenase-2 selective inhibitor is BMS-347070, S-33516, CS-502, darbufelone, LAS 34475, LAS 34556, L-745337, SD-8381, RWJ-63556, L-784512, COX-189, ABT-963, or valdecoxib, or any pharmaceutical salt or prodrug thereof. Compositions, pharmaceutical compositions and kits that can be used with the methods are also described.
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