| 发明名称 |
A DNA ENZYME TO INHIBIT PLASMINOGEN ACTIVATOR INHIBITOR-1 |
| 摘要 |
The present invention provides DNAzymes and ribozymes that specifically clea ve PAI-1-encoding mRNA. The present invention also provides antisense oligonucleotides that specifically inhibit translation of PAI-1-encoding mRN A. The invention also provides various methods of inhibiting the expression of PAI-1, and methods of treating diseases by such. Finally the invention provides pharmaceutical compositions containing the instant DNAzymes, ribozymes, antisense oligonucleotides, or other inhibitors of PAI-1 expressi on as active ingredients.
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| 申请公布号 |
CA2483007(A1) |
申请公布日期 |
2003.11.06 |
| 申请号 |
CA20032483007 |
申请日期 |
2003.04.23 |
| 申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK |
发明人 |
ITESCU, SILVIU |
| 分类号 |
C12N15/09;A61K31/122;A61K31/37;A61K31/616;A61K31/7088;A61K31/727;A61K38/00;A61K38/22;A61K38/46;A61K39/395;A61K45/00;A61K48/00;A61P7/04;A61P9/00;A61P9/02;A61P9/10;A61P11/00;A61P13/12;A61P17/00;A61P27/02;A61P29/00;C07H21/02;C07K14/81;C12N;C12N15/113;C12Q1/68;(IPC1-7):C12N15/11;C07H21/00;C07H21/04;C12N9/22;A61K31/708 |
主分类号 |
C12N15/09 |
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