EGLIN C BASED DRUGS FOR TREATMENT OF DISEASE

摘要

The present invention relates to eglin c variants which inhibit proteases, and in particular to eglin c mutants at adventitious c ontact sites. The present invention also relates to eglin c variants which comprise mutations in both adventitious contact sites and at reactive loop sites. The present invention further relates to methods of preparing the eglin c variants, and methods of using the eglin c variants for treatment of diseases including acute bacterial, viral, and fungal infections.