Cd45 inhibitors

摘要

Substituted phenanthrene-9,10-diones in accord with structural diagram I, compositions thereof and methods for the use thereof, for the treatment of T cell mediated conditions such as autoimmune diseases and organ graft rejection. In compounds of the invention, R<1 >at each occurrence is independently selected from hydrogen, halogen, NH-tosyl, N-di-tosyl, NH2, NO2, NH-CO-R<2>, CO-NH-R<2>, Ar, (CH2)nCH(COOH)R<3 >COR<3 >and NHCOCH2CH(COOH)NHR<4>, where R<2>, R<3 >and R<4 >are a selected from a variety of substituted or unsubstituted alkyl and aryl groupstand oligopeptides.