Two novel camp-specific phosphodiesterase (pde4b)isoforms and related technology

摘要

Two novel cAMP-specific isoforms of rat PDE4B are disclosed. pRPDE90 is a cDNA encoding a 659-amino acid-long protein with a large region corresponding to similar regions found in PDE4B1 and PDE4B3. It is separated from these isoforms by a 17-amino acid region found at its extreme amino-terminal end which shows no homology to any previously-cloned sequence. pRPDE89 is a rat cDNA which encodes a 726-amino acid-long protein which is 96% identical to the human PDE4B1 phosphodiesterase isoform.