Catechol diether compounds as inhibitors of TNF release

摘要

This invention relates to the use of catechol diether compounds for the manufacture of a medicament for use as an inhibitor of tumor necrosis factor (TNF). The catechol diether compounds are useful as inhibitors of TNP per se and in the treatment or alleviation of inflammatory conditionsor disease, including but not limited to rheumatoid arthritis, osteoarthritis, asthma, bronchitis, chronic obstructive airways disease, psoriasis, allergic rhinitis, dermatitis and inflammatory bowel disease, sepsis, septic shock, tubercolosis, graft versus host disease and cachexis associated with AIDS or cancer.