发明名称 |
NOVEL ISOFORMS OF VASCULAR ENDOTHELIAL CELL GROWTH INHIBITOR |
摘要 |
This invention discloses two new VEGI isoforms named VEGI-¿192a< AND VEGI-192b consisting of 192 amino acid residues. These isoforms show endothelial cell-specific expression and share a C-terminal 151-residues segment with the previously described VEGI-174 and VEGI-251. Methods of using these isoforms of VEGI in diagnosing, screening agonist and antagonist of the isoforms, and treating various angiogenesis-related diseases are also disclosed.
|
申请公布号 |
WO03039491(A8) |
申请公布日期 |
2003.10.30 |
申请号 |
WO2002US37426 |
申请日期 |
2002.11.12 |
申请人 |
GEORGETOWN UNIVERSITY;LI, LUYUAN;PAN, HONGGUANG |
发明人 |
LI, LUYUAN;PAN, HONGGUANG |
分类号 |
C12N15/12;A61K38/00;A61K38/17;A61K39/395;A61P43/00;C07K14/47;C07K14/705;C07K16/18;C07K19/00;C12N15/63;(IPC1-7):A61K/ |
主分类号 |
C12N15/12 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|