IDENTIFICATION OF NEURAL DEFECTS ASSOCIATED WITH THE NUCLEOSOM AL ASSEMBLY PROTEIN 1L2 GENE
摘要
A method for screening neural system defects in a human comprises: (A) providing chromosomal material from the human; (B) detecting a modification of the NAP1L2 gene in the chromosomal material, wherein the modification is selected from a) substitution, b) dele-tion, c) frame-shift, or d) insertion that causes a loss of biological function in the NAP1L2 gene; and (C) correlating the modification of the gene with a potential for a neural system defect. The method can also be practiced with the mouse Nap1L2 gene.
申请公布号
WO0185995(A3)
申请公布日期
2003.10.30
申请号
WO2001IB00960
申请日期
2001.05.04
申请人
INSTITUT PASTEUR;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS;AVNER, PHILIP;ROGNER, UTE, CHRISTINE;SPYROPOULOS, DEMETRI;ROUGEULLE, CLAIRE