PLASMA PROTEIN-BINDING LIGANDS

摘要

The invention provides an isolated or purified peptide that binds at least o ne plasma protein. In one embodiment, the isolated or purified peptide binds to fibrinogen, comprises no more that 10 amino acids, and comprises an amino ac id sequence Xaa1-Xaa2-Xaa3-Xaa4-Xaa5, an amino acid sequence Gly-Xaa6-Arg-Xaa7, or an amino acid sequence selected from specific amino acid sequences provid ed herein. Alternatively, the isolated or purified protein binds to .alpha.1 proteinase inhibitor and/or a protein complex comprising Apo-A1 lipoprotein and paraoxonase. The peptide comprises no more than 10 amino acids and comprises an amino acid sequence Xaa8-Xaa8-Xaa1-His-Xaa1-Xaa3, an amino acid sequence His-Xaa8-Xaa9-Xaa1-Xaa10-Xaa2, or an amino acid sequence selected from specific amino acid sequences provided herein. In addition, the inventi on provides isolated or purified peptide that binds to von Willebrand Factor. T he peptide comprises an amino acid sequence Xaa4-Xaa5-Xaa5, an amino acid sequence Tyr-Leu-Xaa11-Xaa4-Xaa12-Thr, or an amino acid sequence selected fr om specific amino acid sequences provided herein.