4-¬(3-methyl-2(3H)-benzothiazolyliden)methylene -quinoline and -pyridine derivatives as reporter groups in probes for analysis of nucleic acids

摘要

Compounds with the chemical structure: where R<1> is a hydrogen or to the nitrogen non-conjugated alkyl group of at most 6 carbon atoms, that may be substituted as specified below, where X is O, S, Se, N-R<5>, where R<5> is a hydrogen or an alkyl group that may be substituted as specified below, or CR<6>R<7>, where R<6> and R<7>, which may be same, are hydrogens or alkyl groups, that may be substituted as specified below, where R<2>, R<3> and R<4>, of which two or all three may be same, are hydrogen, small alkyl groups, that may be substituted as specified below, aryles, or in pair, R<2> and R<4> or R<3> and R<4>, and in combination with two of the ring atoms, make a 5 or 6-membered aromatic ring, that may contain 0-2 heteroatoms such as O, S and N-R<8>, where R<8> is a hydrogen or an alkyl group, that may be substituted as specified below. where n = 0, 1 or 2, where Y is HC=CH, and A and B are both 0 or 1, if A=0 then B=1 and vice versa, where R<9> and R<10>, which may be same, are hydrogens or to the nitrogen non-conjugated alkyl groups, that may be substituted as specified below, and R<1>, R<2>, R<3>, R<4>, R<5>, R<6>, R<7>, R<8>, R<9> and R<10> are hydrocarbon chain, that may have polar residues such as defined in the claims, and one of them has a carboxylic acid group.