| 发明名称 |
S-(+)-ADENOSYLMETHIONINE AND 3'-AZIDO-2',3'-DIDEOXY-NUCLEOSIDE COMPLEXES AS POTENT INHIBITORS OF HIV-REPLICATION |
| 摘要 |
Molecular Complexes, comprising of S-(+)-adenosylmethionine and 3'-azido-2',3'-dideoxy nucleosides are prepared, and shown to have synergistic inhibitory effects on the replication of human-immunodeficiency virus 1 & 2 in vitro and in vivo, particularly on the reverse transcriptase, and having a high therapeutic index.
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| 申请公布号 |
CA2213099(C) |
申请公布日期 |
2003.10.28 |
| 申请号 |
CA19972213099 |
申请日期 |
1997.08.14 |
| 申请人 |
ZIMMERMANN, KURT;PARADIES, H. HENRICH |
发明人 |
ZIMMERMANN, KURT;PARADIES, H. HENRICH |
| 分类号 |
C07H19/06;A61K31/70;A61K31/7042;A61K31/7052;A61K31/7064;A61K31/7068;A61K31/7072;A61K31/7076;A61K31/708;A61K45/00;A61P31/12;A61P31/18;A61P37/04;C07H19/16;(IPC1-7):C07H19/173;C07H19/073 |
主分类号 |
C07H19/06 |
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