发明名称 |
IMPROVED PRODRUGS OF CC-1065 ANALOGS |
摘要 |
Prodrugs of analogs of the anti-tumor antibiotic CC-1065 having a cleavable protective group such as a piperazino carbamate, a 4-piperidino-piperidino carbamate or a phosphate, in which the protecting group confers enhanced water solubility and stability upon the prodrug, and in which the prodrug also has a moiety, such as a disulfide, that can conjugate to a cell binding reagent such as an antibody. The therapeutic use of such prodrug conjugates is also described; such prodrugs of cytotoxic agents have therapeutic use because they can deliver cytotoxic prodrugs to a specific cell population for enzymatic conversion to cytoxic drugs in a targeted fashion. |
申请公布号 |
WO03086318(A2) |
申请公布日期 |
2003.10.23 |
申请号 |
WO2003US07282 |
申请日期 |
2003.03.20 |
申请人 |
IMMUNOGEN, INC.;ZHAO, ROBERT, YONGXIN;CHARI, RAVI, V.J. |
发明人 |
ZHAO, ROBERT, YONGXIN;CHARI, RAVI, V.J. |
分类号 |
C07D401/14;A61K31/404;A61K31/407;A61K31/454;A61K31/4545;A61K31/496;A61K31/661;A61K31/675;A61K47/48;A61P35/00;A61P43/00;C07D209/60;C07D403/14;C07F9/572;C07F9/6558 |
主分类号 |
C07D401/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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