| 发明名称 |
Process for the preparation of ribavirin |
| 摘要 |
<p>A process for the preparation of ribavirin on an industrial scale is described which comprises the reaction of glycosylation of 3-substituted triazoles in the presence of a Lewis acid. Said process comprises: a) the reaction of a triazole of the formula <CHEM> with a protected ribofuranose of the formula <CHEM> b) the removal of the Pg groups and, optionally, the conversion into a carhoxyamide group of the R2 group of the compound obtained of the formula <CHEM></p> |
| 申请公布号 |
EP1281715(B1) |
申请公布日期 |
2003.10.22 |
| 申请号 |
EP20010830510 |
申请日期 |
2001.07.30 |
| 申请人 |
CLARIANT LIFE SCIENCE MOLECULES (ITALIA) SPA |
发明人 |
BANFI, ALDO;DALL'ORO, BRUNO;FRIGERIO, MARCO;MANCINI, ALFREDO |
| 分类号 |
A61K31/7056;A61P31/12;C07H1/00;C07H19/056;(IPC1-7):C07H19/056;A61K31/705 |
主分类号 |
A61K31/7056 |
| 代理机构 |
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代理人 |
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| 主权项 |
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