| 摘要 |
Disclosed are nociceptin ORL-1 receptor agonists of the formula wherein: (a) R<subscript>1 </highlight>is optionally substituted alkyl, fluorenyl, pyrimidinyl or optionally substituted piperidinyl; R<subscript>2 </highlight>is H; and R<subscript>3 </highlight>is -C(H)(R)-NR<subscript>7</highlight>R<subscript>8</highlight>; R is H, optionally substituted aryl or arylalkyl, or heteroaryl; R<subscript>7 </highlight>is -(CH<subscript>2</highlight>)<subscript>x</highlight>R<subscript>9</highlight>, optionally substituted tetrahydronaphthyl, or cycloalkyl; and R<superscript>8 >is H; or R<subscript>7 </highlight>and R<subscript>8 </highlight>together form a substituted piperidinyl or piperazinyl ring; x is 0-10; and R<subscript>9 </highlight>is H, alkoxy, optionally substituted phenyl, naphthyl, heteroaryl, pyrrolidinyl, pyrrolidonyl, optionally substituted piperidinyl or diphenylmethyl; or (b) R<subscript>2</highlight>is -NHR<subscript>7</highlight>or and R<subscript>3 </highlight>is H; pharmaceutical compositions; and methods of using the compounds to treat cough and pain.
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