Methods are provided for the stabilization of proteinases by the covalent attachment of or admixture with water-soluble polymers. The resultant stabilized proteinases have increased stability under the harsh conditions used in industrial genomics, which permits their use in the extraction and isolation of nucleic acids and the identification of disease-related prion proteins at elevated temperatures in solutions containing chaotropic agents, such as sodium dodecyl sulfate, urea or guanidinium salts, conferring advantages for robotic applications.
申请公布号
WO03002716(A3)
申请公布日期
2003.10.16
申请号
WO2002US20417
申请日期
2002.06.28
申请人
MOUNTAIN VIEW PHARMACEUTICALS, INC.
发明人
SHERMAN, MERRY, R.;MARTINEZ, ALEXA, L.;BHASKARAN, SHYAM, S.;WILLIAMS, L., DAVID;SAIFER, MARK, G., P.;FRENCH, JOHN A.