| 摘要 |
PROBLEM TO BE SOLVED: To provide a radiation sensitizer. SOLUTION: The agent contains a pterin derivative of formula I, its cyclized compound or their salts. In formula I, R<SP>1</SP>and R<SP>2</SP>are each a 1-20C alkyl optionally substituted with one or more groups selected from OH, amino group, phosphoric acid group and sulfonic acid group, an acyl group of formula R<SP>3</SP>-CO (R<SP>3</SP>is a 1-4C alkyl), an amino acid residue expressed by formula (a) or H; R<SP>4</SP>is H or a 1-4C alkyl optionally substituted with one group selected from OH, carboxy, carbamoyl, mercapto, methylthio, amino, guanidino, imidazolyl, phenyl, hydroxyphenyl and indolyl; X is formyl or hydroxymethyl; A is a group of formula (Ia); and (n) is 0 or an integer of≥1. COPYRIGHT: (C)2004,JPO
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