| 摘要 |
<p>Unique antigenic epitopes of IgE (designated ige.b1 which are present on IgE-bearing B lymphocytes but not basophils are described. One class of ige.b1 epitopes are at or near the FcεR binding site on IgE. Another class of ige.b1 epitopes are associated with the extracellular segment of the domain of ε chains which anchor IgE to the B cell membrane (ε.mb/ec). Monoclonal antibodies which bind to the ige.b1 epitopes are useful to treat IgE-mediated allergies. The monoclonal antibodies, either alone or as cytotoxin-conjugated immunotoxins, can be used to reduce or deplete IgE-producing B cells in allergy sufferers. Monoclonal antibodies against the idiotypes of the ige.b1 specific antibodies or peptides expressing the epitopes can be used to actively immunize allergy sufferers to attain the same results of administering the monoclonal antibodies.</p> |
