发明名称 |
FABRICATION OF VASCULARIZED TISSUE USING MICROFABRICATED TWO-DIMENSIONAL MOLDS |
摘要 |
Methods and materials for making complex, living, vascularized tissues for organ and tissue replacement, especially complex and/or thick structures, such as liver tissue is provided. Tissue lamina is made in a system comprising an apparatus having (a) a first mold or polymer scaffold, a semi-permeable membrane, and a second mold or polymer scaffold, wherein the semi-permeable membrane is disposed between the first and second molds or polymer scaffolds, wherein the first and second molds or polymer scaffolds have means defining microchannels positioned toward the semi-permeable membrane, wherein the first and second molds or polymer scaffolds are fastened together; and (b) animal cells. Methods for producing complex, three-dimensional tissues or organs from tissue lamina are also provided. |
申请公布号 |
AU2003222035(A1) |
申请公布日期 |
2003.10.13 |
申请号 |
AU20030222035 |
申请日期 |
2003.03.25 |
申请人 |
THE GENERAL HOSPITAL CORPORATION |
发明人 |
KEVIN, R. KING;CHIAO-CHUN WANG;ELI WEINBERG;JOSEPH, P. VACANTI;YOUNG-MOON, MICHAEL SHIN;JENNIFER OGILVIE;ALEXANDER SEVY;TOMOYUKI MAEMURA;OSAMU ISHI;MOHAMMAD, REZA KAAZEMPUR-MOFRAD;JEFFREY, T. BORENSTEIN |
分类号 |
A61F;A61L27/38;B22C9/22;C12M3/04;C12N5/00;C12N5/071 |
主分类号 |
A61F |
代理机构 |
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代理人 |
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