Manual stent manipulation before implantation results in foreign body contamination and increased neointimal hyperplasia. Rinsing commercially available sterile stents with high pressure immediately before implantation eliminates residual surface stent contaminants and reduces inflammation elicited by stent struts. Ex-vivo stent expansion and surface analysis revealed that rinsed stents had fewer surface contaminants than untouched or handled stents. In a porcine stent restenosis model, rinsed stents elicited less inflammation and less neointimal hyperplasia at one month than handled and untouched stents. Pressure-rinsing of coronary stents immediately before implantation reduces inflammation and neointimal hyperplasia.
申请公布号
EP1349518(A2)
申请公布日期
2003.10.08
申请号
EP20020708997
申请日期
2002.01.09
申请人
CAMRUD, ALLAN R.;BAYES-GENIS, ATONI;SCHWARTZ, ROBERT S.
发明人
CAMRUD, ALLAN R.;BAYES-GENIS, ATONI;SCHWARTZ, ROBERT S.