发明名称 |
Continuous release pharmaceutical compositions comprising a polypeptide covalently conjugated to a water soluble polymer |
摘要 |
<p>Pharmaceutical compositions for continuous release of a physiologically active substance in which the physiologically active substance comprises a polypeptide covalently conjugated to a water soluble polymer show particularly desirable release characteristics. Polypeptides for use in the pharmaceutical compositions include G-CSF and solution stable derivatives thereof, human calcitonin and interleukin-2. The material of the composition may be a polylactide or biodegradable hydrogel derived from an amphipathic block copolymer. The compositions enable a therapeutically effective polypeptide to be continuously released over a prolonged period of time following a single administration of the pharmaceutical composition to a patient. <IMAGE></p> |
申请公布号 |
EP0473268(B1) |
申请公布日期 |
2003.10.08 |
申请号 |
EP19910306452 |
申请日期 |
1991.07.16 |
申请人 |
ASTRAZENECA AB |
发明人 |
CAMBLE, ROGER;TIMMS, DAVID;WILKINSON, ANTHONY JAMES |
分类号 |
A61K9/00;A61K9/20;A61K38/00;A61K38/21;A61K38/23;A61K38/27;A61K47/34;A61K47/36;A61K47/48;A61P31/12;A61P35/02;A61P37/04;C07K14/535;(IPC1-7):C07K14/535;A61K47/32;A61K38/19 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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