发明名称 |
Method for producing the anticholinergic agent tiotropium bromide and use of tropenol and tropenol ester |
摘要 |
Tiotropium bromide is produced from di-(2-thienyl)-glycolic acid tropenol ester in a two step process comprising oxidation and subsequent quaternisation. Production of tiotropium bromide (I) comprises oxidation of the di-(2-thienyl)-glycolic acid tropenol ester (II) and quaternisation of the resulting di-(2-thienyl)-glycolic acid scopine ester (III) with methyl bromide. |
申请公布号 |
SK9352003(A3) |
申请公布日期 |
2003.10.07 |
申请号 |
SK20030093520 |
申请日期 |
2001.12.12 |
申请人 |
BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG |
发明人 |
BANHOLZER ROLF;BROEDER WOLFGANG;GRAULICH MANFRED;LUETTKE SVEN;MATHES ANDREAS;MEISSNER HELMUT;SPECHT PETER |
分类号 |
A61K31/46;A61P11/06;A61P11/08;A61P25/00;A61P43/00;C07D451/06;C07D451/10;(IPC1-7):C07D451/10 |
主分类号 |
A61K31/46 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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