发明名称 |
Method of regulating biological activity of pituitary tumor transforming gene (PTTG)1 using PTTG2 |
摘要 |
Disclosed is a method of inhibiting neoplastic cellular proliferation and/or transformation of mammalian breast or ovarian cells, including cells of human origin, in vitro or in vivo. The inventive method involves the use of a pituitary tumor transforming gene (PTTG)2 peptide, which has the ability to regulate endogenous PTTG1 expression and/or function in a dominant negative manner. In some embodiments, the invention is directed to gene-based treatments that deliver PTTG2-encoding polynucleotides to mammalian cells, whether in vitro or in vivo, to inhibit the endogenous expression of PTTG1. Other embodiments are directed to peptide-based treatments that deliver PTTG2 peptide molecules to the cells, which inhibit endogenous PTTG1 expression and/or PTTG1 function. Kits useful in practicing the inventive method are also disclosed.
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申请公布号 |
US2003186902(A1) |
申请公布日期 |
2003.10.02 |
申请号 |
US20010854326 |
申请日期 |
2001.05.11 |
申请人 |
PREZANT TONI RITA;HEANEY ANTHONY P.;MELMED SHLOMO |
发明人 |
PREZANT TONI RITA;HEANEY ANTHONY P.;MELMED SHLOMO |
分类号 |
A01K67/027;A61K31/7088;A61K31/711;A61K35/76;A61K38/00;A61K47/44;A61K48/00;A61P13/12;A61P17/02;A61P27/02;A61P35/00;A61P37/06;A61P43/00;C07K14/47;C07K14/82;C12N5/10;C12N15/09;C12N15/12;C12Q1/02;G01N33/15;G01N33/50;(IPC1-7):A61K48/00;A61K38/17 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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