发明名称 |
HETEROAROMATIC UREA DERIVATIVES AS VR-1 RECEPTOR MODULATORS FOR TREATING PAIN |
摘要 |
The present invention provides compounds of formula (I); pharmaceutically acceptable salts and N-oxides thereof in which A, B, D and E are C or N with the proviso that one or more are N, R1, R2, R3, R4, R5 and R6 are simple substituents, n is 0-3 and y is an aryl, heteroaryl, carbocyclyl or fused- carbocyclyl group; as VR-1 antagonists for treating conditions or diseases i n which pain and/or inflammation predominates; the use of the same for manufacturing medicaments, pharmaceutical compositions comprising them and methods of treatment utilising them.
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申请公布号 |
CA2479150(A1) |
申请公布日期 |
2003.10.02 |
申请号 |
CA20032479150 |
申请日期 |
2003.03.21 |
申请人 |
MERCK SHARP & DOHME LIMITED |
发明人 |
JONES, A. BRIAN;HOLLINGWORTH, GREGORY JOHN;DOUGHTY, VICTORIA ALEXANDRA;BROWN, REBECCA ELIZABETH;MOYES, CHRISTOPHER RICHARD;LINDON, MATTHEW JOHN;ROGERS, LAUREN |
分类号 |
C07D237/28;A61K31/427;A61K31/47;A61K31/4709;A61K31/4725;A61K31/502;A61K31/506;A61K31/5377;A61P1/04;A61P11/00;A61P11/06;A61P13/10;A61P19/02;A61P19/06;A61P25/02;A61P25/04;A61P25/06;A61P29/00;A61P37/02;C07D215/38;C07D217/02;C07D217/08;C07D217/14;C07D217/16;C07D217/22;C07D217/24;C07D217/26;C07D401/12;C07D405/12;C07D413/12;C07D417/12;C07D417/14;(IPC1-7):C07D215/38;C07D521/00;C07D401/14;C07D215/40;A61K31/470;A61K31/472;A61K31/501 |
主分类号 |
C07D237/28 |
代理机构 |
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代理人 |
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地址 |
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