COMPOUNDS COMPRISING PSEUDO-AMINO ACIDS

摘要

This invention relates to compounds, and in particular to polypeptides, their use and methods for their production. These polypeptides are produced from "pseudo-cysteine" amino acids that facilitate the assembly of polypeptides by native chemical ligation. The invention provides a compound comprising a polypeptide, the polypeptide having at a C-terminal end a pseudo amino acid, the pseudo amino acid having a side chain containing a 1-amino-2-thiol moiety. For example the polypeptide comprises the structure: formula (I) wherein : R is a polypeptide chain; X is a linker.