发明名称 |
TECHNETIUM-DIPYRIDINE COMPLEXES, AND METHODS OF USE THEREOF |
摘要 |
<p>One aspect of the invention relates to novel complexes of technetium (Tc) wi th various heteroaromatic ligands, e.g., pyridyl and imidazolyl ligands, and their use in radiopharmaceuticals for a variety of clinical diagnostic and therapeutic applications. Another aspect of the invention relates to novel pyridyl ligands that form a portion of the aforementioned complexes. Methods for the preparation of the technetium complexes are also described. Another aspect of the invention relates to novel pyridyl ligands based on derivatize d lysine, alanine and bis-amino acids for conjugation to small peptides by sol id phase synthetic methods. Additionally, the invention relates to methods for imaging regions of a mammal using the complexes of the invention.</p> |
申请公布号 |
CA2478305(A1) |
申请公布日期 |
2003.09.25 |
申请号 |
CA20032478305 |
申请日期 |
2003.03.11 |
申请人 |
BIOSTREAM, INC. |
发明人 |
BABICH, JOHN W.;MARESCA, KEVIN P. |
分类号 |
C07D213/36;A61K51/00;C07D213/38;C07F13/00;(IPC1-7):A61K49/00 |
主分类号 |
C07D213/36 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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