发明名称 |
Method for diagnosing and treating dentinogenesis imperfecta type II by using dentin sialophsphoprotein (dspp)gene and its encoding product |
摘要 |
The invention has disclosed a method for diagnosis of dentinogenesis imperfecta type II (DGI-II) and/or dentinogenesis imperfecta type II with deafness (DGI-II with deafness). Said method comprises the steps of detecting the DSPP gene, transcript and/or protein in said subject and comparing it with the normal DSPP gene, transcript and/or protein to determine whether there is any variation, wherein said variation indicates that the possibility of suffering DGI-II and/or DGI-II with deafness in said subject is higher than the normal population. The present invention also discloses the method and pharmaceutical composition for treating DGI-II and/or DGI-II with deafness.
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申请公布号 |
US2003180280(A1) |
申请公布日期 |
2003.09.25 |
申请号 |
US20030363798 |
申请日期 |
2003.03.05 |
申请人 |
KONG XIANGYIN;XIAO SHANGXI;ZHAO GUOPING;YU CHUAN;HU LANDIAN |
发明人 |
KONG XIANGYIN;XIAO SHANGXI;ZHAO GUOPING;YU CHUAN;HU LANDIAN |
分类号 |
A61K38/00;G01N33/68;(IPC1-7):A61K38/46;C12Q1/68 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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