发明名称 |
NEUE KÜGELCHEN MIT KONTROLLIERTER FREISETZUNG, EIN VERFAHREN ZU DEREN HERSTELLUNG UND DIESE ENTHALTENDE FORMULIERUNG DES TYPS MULTIPLE UNIT |
摘要 |
A controlled release bead comprises: (i) a core unit of a substantially water-soluble or water-swellable inert material; (ii) a first layer on the core unit of a substantially water-insoluble polymer; (iii) a second layer covering the first layer and containing an active ingredient; and (iv) a third layer of polymer on the second layer effective for controlled release of the active ingredient, wherein the first layer is adapted to control water penetration into the core. A method of producing the controlled release bead is also disclosed. |
申请公布号 |
DE69910604(D1) |
申请公布日期 |
2003.09.25 |
申请号 |
DE1999610604 |
申请日期 |
1999.11.11 |
申请人 |
PHARMACIA AB, STOCKHOLM |
发明人 |
GREN, TORKEL;RINGBERG, ANDERS;WIKBERG, MARTIN;WALD, J. |
分类号 |
A61K9/60;A61K;A61K9/16;A61K9/26;A61K9/50;A61K9/52;A61K9/58;A61K9/70;A61K31/135;A61K31/137;A61K47/38;A61P;A61P1/00;A61P13/02;A61P13/10 |
主分类号 |
A61K9/60 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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