| 摘要 |
A stable drug dosage form prepared by compression techniques comprising: a thyroid hormone susceptible to moisture induced degradation, and particles of at least one pharmaceutically acceptable excipient, each particle having an exterior surface, an interior, equilibrium moisture disposed within the interior of the particles, the thyroid hormone being in contact with the exterior surface of the particles of the dosage form prepared by: admixing the thyroid hormone and the at least on excipient; and compacting the thyroid hormone and the excipient into unit dosage forms using compression pressures of less than about 5000 psi/g; wherein the compression pressure limits the amount of equilibrium moisture available to react with the thyroid hormone at the exterior surface of the particles of at least one pharmaceutically acceptable excipient; and the drug dosage form exhibits improved stability to moisture-induced degradation of the hormone as compared with a tabletted form of the hormone.
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