| 摘要 |
The present invention relates to microbial infections, including those involving multidrug resistance and, in particular, to opioid compounds that are inhibitors of drug transporters of the ABC protein superfamily. The invention relates to methods of treating microbial infections using anti-microbial agents and opioid inhibitors of such transporters. The invention also relates to methods for selecting or identifying compounds for the ability to inhibit drug transporter proteins and to methods of inhibiting drug transporter proteins. The invention concerns the new use of opioid receptor antagonists in the treatment of microbial infections, including multidrug resistant microbial infections. |
