发明名称 |
Method of screening for antiandrogen agent |
摘要 |
A novel action mechanism wherein androgen receptor (AR) is activated by the interaction between cyclin E and the androgen receptor was revealed. This activation is resistant to existing anti-androgen agents and both androgen receptor ligand-dependent and independent activations were found to participate in this mechanism. Methods of screening for anti-androgen agents using cyclin E are also provided by the present invention. Based on the findings as described above, novel anti-androgen agents can be screened. These anti-androgen agents are expected to be efficacious also against pathological conditions that have become resistant to existing anti-androgen agents. Thus, the instant invention opens up new possibilities for treatment using anti-androgen agents that had their limitations until now.
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申请公布号 |
US2003175817(A1) |
申请公布日期 |
2003.09.18 |
申请号 |
US20030203568 |
申请日期 |
2003.03.14 |
申请人 |
IKEDA KYOJI;NAKANISHI MAKOTO;KATO SHIGEAKI |
发明人 |
IKEDA KYOJI;NAKANISHI MAKOTO;KATO SHIGEAKI |
分类号 |
A61P5/28;G01N33/74;(IPC1-7):G01N33/53;A61K31/56;A61K38/24;C07J53/00;C07K14/575;G01N33/567 |
主分类号 |
A61P5/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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