| 摘要 |
The present invention provides an isolated nucleic acid molecule having a variation of the IL-13 encoding sequence shown in FIG. (1) wherein the variation is at least one of G to C at position +543nt and/or C to T at position +1922nt and/or G to A at position +2043nt and/or C to A at position +2579nt upstream of the initiation codon. The invention further provides an isolated amino acid sequence encoding a variant IL-13 containing glutamine at amino acid position 130, and the use of said amino acid sequence in a method of producing an antibody. Additionally, there is provided a method of detecting susceptibility or resistance to a disorder associated with an immune response comprising testing nucleic acid from an individual for the presence of a variation in the nucleotide sequence encoding IL 13.
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