COMPOSITIONS AND METHODS FOR THE TREATMENT OF ANORECTAL DISORDERS

摘要

Compositions and methods for the treatment of patients with anorectal disorders including colostomy are provided in which certain compounds including, but not limited to, NO donors, calcium channel blockers, cholinergic modulators (including acetylcholine storage blocking agents and acetylcholine vesicle storage blocking agents), $g(a)-adrenergic receptor antagonists (including $g(a)¿1<-adrenergic antagonists and $g(a)¿2?-adrenergic antagonists), $g(b)-adrenergic receptor agonists (including $g(b)¿2?-adrenergic antagonists and $g(b)¿3?-adrenergic antagonists), phosphodiesterase inhibitors, cAMP-dependent protein kinase activators (e.g., cAMP mimetics), superoxide scavengers, potassium channel activators (including ATP-sensitive potassium channel activators and activators of the Maxi-K channels), estrogen-like compounds, testosterone-like compounds, benzodiazepines, adrenergic nerve inhibitors, antidiarrheal agents, HMG-CoA reductase inhibitors, smooth muscle relaxants, adenosine receptor modulators, adenylyl cyclase activators, endothelin receptor antagonists, bisphosphonates, cGMP-dependent protein kinase activators (e.g., cGMP mimetics), and combinations thereof are used.