发明名称 |
Retroviral vectors comprising an enhanced 3' transcription termination structure |
摘要 |
The invention provides novel retroviral vectors that have enhanced transcription termination structures. The termination structures comprise one or several heterologous upstream transcription termination enhancer (UE) sequences, or one or more additional copies of endogenous UE sequences operably associated with the 3' LTR polyadenylation signal. The retroviral vectors of the invention have various improved properties over conventional vectors, including stronger gene expression, enhanced vector titer and reduced interference with host cell gene expression resulting from read-through of vector initiated transcriptional events.
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申请公布号 |
US6620595(B2) |
申请公布日期 |
2003.09.16 |
申请号 |
US20010855159 |
申请日期 |
2001.05.14 |
申请人 |
UNIVERSITY OF SOUTHERN CALIFORNIA |
发明人 |
CANNON PAULA MARIE;BARCOVA MARIA |
分类号 |
C12N15/09;A61K35/76;A61K48/00;C12N5/10;C12N7/00;C12N15/867;(IPC1-7):C12P21/00;C07H21/04;C12M15/867 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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