| 发明名称 |
GLIAL CELL LINE-DERIVED NEUTROPHIC FACTOR |
| 摘要 |
A novel neurotrophic factor referred to as a glial cell line-derived neurotrophic factor (GDNF) has been identified and isolated from serum free growth conditioned medium of B49 glioblastoma cells. Rat and human genes encoding GDNF have been cloned and sequenced. A gene encoding GDNF has been subcloned into a vector, and the vector has been used to transform a host cell in order to produce biologically active GDNF in a recombinant DNA process. |
| 申请公布号 |
CA2119463(C) |
申请公布日期 |
2003.09.16 |
| 申请号 |
CA19922119463 |
申请日期 |
1992.09.17 |
| 申请人 |
SYNERGEN, INC. |
发明人 |
LIN, LEU-FEN H.;COLLINS, FRANKLIN D.;DOHERTY, DANIEL H.;LILE, JACK;BEKTESH, SUSAN |
| 分类号 |
A61K38/00;A61K9/00;A61K9/22;A61K31/00;A61K39/395;A61M37/00;A61P25/00;A61P25/16;A61P25/26;A61P25/28;C07K1/20;C07K1/22;C07K14/47;C07K14/475;C07K14/52;C07K16/00;C07K16/24;C12N;C12N1/21;C12N5/02;C12N5/10;C12N15/09;C12N15/12;C12P21/02;C12P21/08;C12R1/19;C12R1/91;(IPC1-7):C12N15/18;C07K1/113;A61K38/18;A61K35/30;C07K14/48 |
主分类号 |
A61K38/00 |
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