INDIVIDUALIZED ANTI-CANCER ANTIBODIES

摘要

The present invention relates to a method for producing patient specific ant i- cancer antibodies using a novel paradigm of screening. By segregating the an ti- cancer antibodies using cancer cell sytotoxicity as an end point, the proces s makes possible the production of anti-cancer antibodies customized for the individual patient that can be used for therapeutic and diagnostic purposes. The invention further relates to the process by which the antibodies are mad e and to their methods of use. The antibodies can be made specifically for one tumor derived from a particular patient and are selected on the basis of the ir cancer cell cytotoxicity and simultaneous lack of toxicity for non-cancerous cells. The antibodies can be used in aid of staging and diagnosis of a cance r, and can be used to treat tumor metastases. The anti-cancer antibodies can be conjugated to red blood cells obtained from that patient and re-infused for treatment of metastases based upon the recognition that metastatic cancers a re usually well vascularized and the delivery of anti-cancer antibodies by red blood cells can have the effect of concentrating the antibodies at the site of the tumor.