发明名称 |
METHODS OF TREATING p38 KINASE-ASSOCIATED CONDITIONS AND PYRROLOTRIAZINE COMPOUNDS USEFUL AS KINASE INHIBITORS |
摘要 |
Methods of treating one or more conditions associated with p38 kinase activity are disclosed comprising administering to a patient in need thereof at least one compound having the formula (I): or a pharmaceutically acceptable salt, prodrug, or solvate thereof, wherein R3 is hydrogen, methyl, perfluoromethyl, methoxy, halogen, cyano, or NH2, preferably methyl, and X, R1 through R6, and Z are as described in the specification. Advantageously the groups ZR4R5 taken together comprise an NH-subsituted aryl. |
申请公布号 |
WO0240486(A3) |
申请公布日期 |
2003.09.12 |
申请号 |
WO2001US49982 |
申请日期 |
2001.11.07 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY;LEFTHERIS, KATERINA;BARRISH, JOEL;HYNES, JOHN;WROBLESKI, STEPHEN, T. |
发明人 |
LEFTHERIS, KATERINA;BARRISH, JOEL;HYNES, JOHN;WROBLESKI, STEPHEN, T. |
分类号 |
A61K31/53;A61K31/5377;A61K31/551;A61P1/04;A61P3/10;A61P9/10;A61P11/00;A61P11/06;A61P17/02;A61P17/06;A61P19/02;A61P19/06;A61P19/10;A61P25/28;A61P29/00;A61P31/14;A61P37/06;A61P39/02;A61P43/00;C07D;C07D209/00;C07D253/00;C07D471/00;C07D487/00;C07D487/04;C07D519/00 |
主分类号 |
A61K31/53 |
代理机构 |
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