BIARYL DERIVATIVES AS GPR120 AGONISTS

摘要

The present invention relates to biaryl derivatives of Formula 1, a method for preparing the same, a pharmaceutical composition comprising the same and use thereof. The biaryl derivatives of Formula 1 according to the present invention promote GLP-1 formation in the gastrointestinal tract and improve insulin resistance in the liver or in muscle due to anti-inflammatory action in macrophages, lipocytes, etc., and can accordingly be effectively used for preventing or treating diabetes, complications of diabetes, obesity, non-alcoholic fatty liver, steatohepatitis, osteoporosis or inflammation.

主权项

1. Biaryl derivatives of Formula 1, or pharmaceutically acceptable salts or isomers thereof: wherein, A and B represent independently phenyl or pyridine, any one of R1-D- and R2-E- cannot exist, D and E represent independently carbon, nitrogen, oxygen or sulfur, or represent direct bond, and any one of R1 and R2 cannot exist, or R1 and R2 represent independently hydrogen, halogen, optionally substituted C1-C6-alkyl, C3-C10-cycloalkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C10-heterocycloalkyl, C1-C6-alkyl-C3-C10-cycloalkyl, C1-C6-alkyl-C3-C10-heterocycloalkyl, aryl, C1-C6-alkylaryl, heteroaryl or C1-C6-alkyl-C5-C6-heteroaryl, and when D and E represent nitrogen or carbon, R1 and R2 can represent two or three optionally substituted C1-C6-alkyl, C3-C10-cycloalkyl, C2-C6 alkenyl, C2-C6-alkynyl, C1-C6-alkyl-C3-C10-cycloalkyl, aryl or C1-C6 alkylaryl which may be the same or different, G represents -J-(CR5R6)p, wherein J represents oxygen or sulfur, R5 and R6 represent independently hydrogen, halogen, optionally substituted alkyl or cycloalkyl, hydroxyl or amine, and R5 and R6 which are substituted at the same or different carbon may be connected to form optionally substituted cycloalkyl or cycloheteroalkyl, R3 and R4 cannot independently exist depending on the number of m or n, or represent independently hydrogen, halogen or optionally substituted C1-C6-alkyl or C1-C6-alkoxy, R7 represents hydrogen, alkyl or cycloalkyl, m and n represent independently an integer of 0 to 5, and p represents an integer of 1 to 6.