| 摘要 |
The invention relates to isolated antigenic polypeptides obtainable by a process comprising the steps of: 1- selecting on the basis of sequence analysis those of the polypeptides which are either located in the outermembrane or secreted by the bacteria, 2- identifying the genes coding for said polypeptides which are conserved in B2/D clinical isolates, 3- purifying the polypeptides identified in step 1, which are found in step 2 to be conserved in B2/D isolates, 4- testing the polypeptides for immunogenicity using animals models. <??>Application for making vaccines compositions.
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