METHOD AND COMPOSITION FOR DETECTION OF ONCOGENIC HPV

摘要

Probes for the detection of oral oncogenic human papillomavirus (HPV) are described. The probe includes a polynucleotide having at least 90% sequence identity to a polynucleotide complementary to a microRNA that has altered expression in response to oncogenic HPV infection. A method for detecting oncogenic HPV in a subject is also described. The method comprises the steps of (A) providing a sample from a subject; (B) measuring the expression level of a microRNA having altered expression in response to oncogenic HPV infection using a probe; and (C) determining that the subject is infected by an oncogenic HPV if the expression level is increased or decreased in comparison with a control.

主权项

1. A probe for detecting oncogenic Human papillomavirus (HPV), comprising a polynucleotide that has at least 90% sequence identity to a polynucleotide complementary to at least one microRNA that has altered expression in response to oncogenic HPV infection.