发明名称 |
Process for obtaining quinapryl hydrochloride and solvates useful for isolating and purifying quinapryl hydrochloride |
摘要 |
The process for obtaining quinapril hydrochloride (I) comprises the stages of: a) hydrogenolysis of the benzyl ester of quinapril (II) by treatment in an alcoholic solvent, with concentrated hydrochloric acid or a solution of hydrogen chloride in isopropanol, and hydrogenation; b) removal of the solvent; c) addition of toluene to precipitate the quinapril hydrochloride as a toluene solvate; d) treatment of said solvate with a Class 3 solvent which forms a solvate of quinapril hydrochloride from which it can be removed by drying without degrading; and e) drying of the solvate from step d) to yield quinapril hydrochloride (I), an antihypertensive agent.
|
申请公布号 |
US6617457(B1) |
申请公布日期 |
2003.09.09 |
申请号 |
US20020424673 |
申请日期 |
2002.06.17 |
申请人 |
ESTEVE QUIMICA, S.A. |
发明人 |
MONSALVATJE LLAGOSTERA MONTSERRAT;BARTRA SANMARTI MARTI;TOMAS NAVARRO JAIME;PUIG TORRES SALVADOR |
分类号 |
A61K31/472;A61P9/12;A61P43/00;C07D217/26;(IPC1-7):C07D217/26 |
主分类号 |
A61K31/472 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|