发明名称 |
CONVECTION-ENHANCED DRUG DELIVERY DEVICE AND METHOD OF USE |
摘要 |
An implantable drug delivery system includes an infusion pump assembly with a fluid outlet, a fluid delivery pathway extending from the pump outlet to a target tissue site; and a controlled release material unit positioned in the fluid deliver y pathway to release a drug or bioactive material into the delivery pathway. The pump assembly delivers fluid as a high flow infusion flow in said pathway, entraining drug material released by the release unit and establishing a pressure gradient at the distal end of the pathway that results in convection-enhanced transport such that the released drug(s) or treatment material enter the target tissue site with enhanced penetration depth and/or concentration. The pump delivers a carrier fluid that may reside in an external or in an implanted reservoir, or that may be an endogenous fluid, such as plasma or CSF.
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申请公布号 |
CA2420584(A1) |
申请公布日期 |
2003.09.06 |
申请号 |
CA20032420584 |
申请日期 |
2003.03.03 |
申请人 |
CODMAN & SHURTLEFF, INC. |
发明人 |
ROHR, WILLIAM L.;KONIECZYNSKI, DAVID D.;DEXTRADEUR, ALAN J. |
分类号 |
A61M37/00;A61K9/22;A61M5/142;A61M25/00;(IPC1-7):A61M5/168;A61M5/172 |
主分类号 |
A61M37/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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