| 摘要 |
Agents for treating, preventing or ameliorating diseases comprise a peroxisome proliferator-activator receptor activator selected from ketone compounds (I) - (V) or their salts or solvates, a hop extract or a modified hop extract. Agents for treating, preventing or ameliorating diseases comprise a peroxisome proliferator-activator receptor activator selected from ketone compounds of formula (I) - (V) or their salts or solvates, a hop extract or a modified hop extract. [Image] R 1>, R 2>, R 1> 0>, R 1> 9>1-6C alkyl or 2-6C alkenyl; R 3>, R 4>OH, 1-6C alkyl or 2-6C alkenyl; R 5> - R 7>, R 1> 1>, R 1> 2>, R 1> 6> - R 1> 8>H, 1-6C alkyl or 2-6C alkenyl; R 8>, R 9>H, OH, 1-6C alkyl, 2-6C alkenyl, COR 1> 0> or CH(OH)R 1> 0>; R 1> 3>, R 1> 4>OH, 1-6C alkyl, 2-6C alkenyl, COR 1> 0> or CH(OH)R 1> 0>; and provided that R 1> and R 2>, R 8> and R 9> and R 1> 3> and R 1> 4> are not both OH. An independent claim is also included for foods containing the agents. ACTIVITY : Anorectic; Antidiabetic; Antilipemic. In tests, administration of isohumulone at 0.5 weight% in the diet of C57BL/6 mice fed a high fat diet, significantly (by at least 5%) reduced blood cholesterol levels from 2 weeks. MECHANISM OF ACTION : PPAR-Agonist. |
