There is provided a method of forming a multimeric complex having affinity for a target. The method comprises: obtaining a plurality of self-assembly molecules, said self-assembly molecules including complementary self-assembly units such as verotoxin subunit B, each of which is operatively connected to an interaction domain such as a single domain antibody specific for the target; and combining said self-assembly molecules such that at least three said self-assembly units simultaneously bind to one another so as to permit the single domain antibodies to bind the target.
申请公布号
WO03046560(A3)
申请公布日期
2003.09.04
申请号
WO2002CA01829
申请日期
2002.11.29
申请人
NATIONAL RESEARCH COUNCIL OF CANADA;MACKENZIE, ROGER, C.;ZHANG, JIANBING