A method for identifying a vaccine candidate, said method comprising selecti ng a protein from the proteome of a target organism on the basis of a property selected from a biophysical property or the amino acid composition of that protein. For example, using this method a first set of data for a said property of a one or more vaccine antigens of a particular genus is collecte d, and a control set of data for said property of one or more random proteins from the same genus is also collected. These datasets are then compared and statistical differences noted. The proteome of a target species may then be examined and one or more vaccine candidates selected from that proteome on t he basis that they have a property more similar to that of the first set of dat a.
申请公布号
CA2477309(A1)
申请公布日期
2003.09.04
申请号
CA20032477309
申请日期
2003.02.25
申请人
THE SECRETARY OF STATE FOR DEFENCE
发明人
MILLER, JULIE;DUFFIELD, MELANIE LORRAINE;LINGARD, BRYAN;MAYERS, CARL NICHOLAS;ROWE, SONYA CLAIRE;TITBALL, RICHARD WILLIAM