发明名称 |
THE LECTIN-LIKE DOMAIN OF THROMBOMODULIN AND ITS THERAPEUTIC USE |
摘要 |
In the present invention the in vivo role of the N-terminal lectin-like domain of thrombomodulin was studied by using homologous recombination in murine ES cells to create mutant mice that lack this region of thrombomodulin. Phenotypic analysis shows that said mice respond identically to their wild type littermates following pro-coagulant challenges meaning that the protein C pathway is not altered by the mutation. However, following several inflammatory stimuli, it was observed that the mutant mice showed an elevated neutrophil extravasation in several organs. In the present invention it is found that leukocyte adhesion could be abrogated by addition of recombinant lectin-domain meaning that said domain has direct anti-inflammatory properties which means that the lectin-like domain can be used to manufacture a medicament useful for the treatment of a variety of inflammatory disease processes. |
申请公布号 |
WO02096947(A3) |
申请公布日期 |
2003.09.04 |
申请号 |
WO2002EP05727 |
申请日期 |
2002.05.24 |
申请人 |
VLAAMS INTERUNIVERSITAIR INSTITUUT VOOR BIOTECHNOLOGIE VZW;D. COLLEN RESEARCH FOUNDATION;CONWAY, EDWARD, M.;COLLEN, DESIRE |
发明人 |
CONWAY, EDWARD, M.;COLLEN, DESIRE |
分类号 |
A61K38/00;A61K38/36;C07K14/745;C12N5/10;C12N15/12 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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