发明名称 |
THERAPEUTIC REGULATION OF DEOXYRIBONUCLEASE-1-LIKE-3 ACTIVITY |
摘要 |
Deoxyribonuclease 1-like 3 (D3) hydrolyzes lipid-complexed DNA and decreases transfection efficiency in liposomal transfection (lipofection) systems. Accordingly, D1 L3 provides a more accurate test of the efficiency of lipid/liposomal based gene therapy than current standards using deoxyribonuclease 1 (Dl). Moreover, it has been found that mice with systemic lupus erythematosus (lupus) have lowered D1 L3 activity. Therefore, differing therapeutic benefits may result from either the upward or downward therapeutic regulation of D1 L3 activity. For example, blocking D1 L3 activity enhances liposomal transfection for gene therapy, while increasing D 1 L3 activity may enhance destruction of pathogenic DNA, whether viral, bacterial or endogenous. Destruction of pathogenic DNA may provide treatment for lupus, or viral and oncogenic diseases. |
申请公布号 |
WO03072741(A2) |
申请公布日期 |
2003.09.04 |
申请号 |
WO2003US05654 |
申请日期 |
2003.02.26 |
申请人 |
SOUTHERN ILLINOIS UNIVERSITY;SCHNEIDER, MICHAEL, C.;WILBUR, ANDREW |
发明人 |
SCHNEIDER, MICHAEL, C.;WILBUR, ANDREW |
分类号 |
A61K9/127;A61K38/21;A61K48/00;C12N9/22;C12N15/88 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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