发明名称 |
TARGETS AND SCREENS FOR AGENTS USEFUL IN CONTROLLING PARASITIC NEMATODES |
摘要 |
The invention provides methods and reagents for identifying compounds that exhibit anti-nematode activity and compounds that potentiate the effects of other anti-nematode agents. The invention provides methods foridentifying modulators of nematode xenobiotic sensing nuclear receptors. The invention also provides methods for screening for anti-nematode compounds using sensitized nematode strains and further provides such sensitized strains. The invention further provides methods and screens for identifying new biological targets for anti-nematode compounds, e.g., for identifying nematode genes and proteins towards which anti-nematode compounds can be developed. The invention provides methods for controlling parasitic nematodes using compounds identified in the inventive screens. In addition, the invention provides sensitized nematode strains and methods for using such strains to enhance identification of compounds in the context of a wide variety of nematode model screening systems and strains. |
申请公布号 |
WO02074923(A3) |
申请公布日期 |
2003.09.04 |
申请号 |
WO2002US08336 |
申请日期 |
2002.03.20 |
申请人 |
CAMBRIA BIOSCIENCES |
发明人 |
LIU, LEO, X.;SLUDER, ANN;PROVOST, CHRIS;LINDBLOM, TIMOTHY;SUTHERLIN, MARIE |
分类号 |
C07K14/435;G01N33/50;G01N33/53;G01N33/573 |
主分类号 |
C07K14/435 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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