发明名称 |
Clinical grade vectors based on natural microflora for use in delivering therapeutic compositions |
摘要 |
<p>Clinical grade vectors comprising transformed microflora vector having at least one transforming nucleic acid sequence containing at least one gene of interest are provided. The transforming nucleic acid encodes for a therapeutic polypeptide that is delivered to the host in need thereof topically, orally, intranasally and/or transderamally. The clinical grade vectors are derived from lactic acid bacteria, yeast and other non-pathogenic microorganisms and have been provided with selective/and or reporter genes that do not rely on antibiotic resistance. Moreover, the clinical grade vectors are provided with phenotypic and/or genotypic traits that limit the ex vivo dissemination of transforming nucleic acid sequence(s). Also provided are methods and compositions useful in treating diseases in animals.</p> |
申请公布号 |
AU2003210689(A1) |
申请公布日期 |
2003.09.02 |
申请号 |
AU20030210689 |
申请日期 |
2003.01.27 |
申请人 |
SYMBIGENE, INC. |
发明人 |
ZHIQING ZHANG;XIAOLI FU;SHERRY NOURAINI;WEI CHEN |
分类号 |
A61K9/18;A61K35/12;A61K38/18;A61K38/19;A61K38/20;A61K38/21;A61K38/27;A61K38/28;A61K38/29;A61K39/00;A61K39/02;A61K39/12;A61K39/145;A61K39/15;A61K39/29;A61K48/00;C12N15/74;(IPC1-7):C07H21/02;C07H21/04;C12N15/00;C12N1/12;A01N43/04;C12N15/63;C12N1/14;C12N1/00 |
主分类号 |
A61K9/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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