| 摘要 |
THIS INVENTION RELATES TO A PROCESS FOR RESOLVING 1-AZABICYCLO[2.2.2JOCTAN-3-AMINE, 2-(DIPHENYLMETHYL)-N-[[2-METHOXY-5-(1-METHYLETHYL)PHENYLJMETHYLJ COMPRISING REACTING 1-AZABICYCLO [2.2.2J OCTAN-3-AMINE, 2-( DIPHENYLMETHYL)-N-[[2-METHOXY-5-(1-METHYLETHYL)PHENYLJMETHYLJ WITH 1 R-(-)-1 O-CAMPHORSUTFONIC ACID IN SOLVENT CAPABLE OF DISSOLVING BOTH OF THE FOREGOING REAGENTS, AND SELECTIVELY DISSOLVING THE CAMPHORSULFONIC ACID SALT OF THE CORRESPONDING (2R,3R) ENANTIOMER RELATIVE TO THE (25,35) ENANTIOMER, TO FORM THE CAMPHORSULFONIC ACID SALT OF (25, 35)-1-AZABICYCLO [2.2.2]OCTAN-3-AMINE, 2-(DIPHENYLMETHYL)-N-[[2-METHOXY-5-(1-METHYLETHYL)PHENYL]METHYL], AND THEN OPTIONALLY HYDROLYZING SUCH SALT TO OBTAIN THE FREE BASE OF THE (25, 35) ENANTIOMER.
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