发明名称 |
Tumor necrosis factor-gamma |
摘要 |
Human TNF-gamma-alpha and TNF-gamma-beta polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides to inhibit cellular growth, for example in a tumor or cancer, for facilitating wound-healing, to provide resistance against infection, induce inflammatory activities, and stimulating the growth of certain cell types to treat diseases, for example restenosis. Also disclosed are diagnostic methods for detecting a mutation in the TNF-gamma-alpha and TNF-gamma-beta nucleic acid sequences or overexpression of the TNF-gamma-alpha and TNF-gamma-beta polypeptides. Antagonists against such polypeptides and their use as a therapeutic to treat cachexia, septic shock, cerebral malaria, inflammation, arthritis and graft-rejection are also disclosed.
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申请公布号 |
NZ509560(A) |
申请公布日期 |
2003.08.29 |
申请号 |
NZ19990509560 |
申请日期 |
1999.02.08 |
申请人 |
HUMAN GENOME SCIENCES, INC |
发明人 |
YU, GUO-LIANG;NI, JIAN;ROSEN, CRAIG A;ZHANG, JUN |
分类号 |
C12N15/09;A61K31/7088;A61K38/00;A61K39/395;A61K39/40;A61K39/42;A61K48/00;A61P29/00;A61P35/00;C07H21/04;C07K14/525;C07K16/24;C12N1/15;C12N1/19;C12N1/21;C12N5/00;C12N5/02;C12N5/10;C12N15/00;C12N15/28;C12N15/63;C12N15/70;C12N15/74;C12P21/00;C12P21/02;C12P21/06;(IPC1-7):C12N15/00;C12N15/11;C12N15/03;C07K1/00;C07K16/00;C07K16/46;A61K38/19;A61K39/00;C12Q1/68;G01N33/53;G01N33/50;G01N33/566;G01N33/48 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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